| 1. Round | 27/03/2016 | Vancouver Whitecaps | - | Houston Dynamo | 1:0 | ||||
| 2. Round | 24/04/2016 | Columbus Crew | - | Houston Dynamo | 1:0 | ||||
| 3. Round | 08/05/2016 | Houston Dynamo | - | Sporting Kansas City | 2:0 | ||||
| 3. Round | 12/05/2016 | San Jose Earthquakes | - | Houston Dynamo | 3:1 | ||||
| 5. Round | 24/07/2016 | Houston Dynamo | - | Vancouver Whitecaps | 0:0 | ||||
| 5. Round | 01/08/2016 | Houston Dynamo | - | San Jose Earthquakes | 1:1 |  |
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| 6. Round | 07/08/2016 | Impact de Montréal | - | Houston Dynamo | 1:0 | ||||
| 6. Round | 15/08/2016 | Houston Dynamo | - | Toronto FC | 1:1 |  |
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| 8. Round | 16/10/2016 | Houston Dynamo | - | Los Angeles Galaxy | 0:1 |
Gambia