| 4. Round | 22/05/2022 | Charlotte FC | - | Vancouver Whitecaps | 2:1 | ||||
| 4. Round | 30/05/2022 | Seattle Sounders | - | Charlotte FC | 2:1 | ||||
| 6. Round | 01/07/2022 | Charlotte FC | - | Austin FC | 0:1 | ||||
| 6. Round | 24/07/2022 | Toronto FC | - | Charlotte FC | 4:0 | ||||
| 7. Round | 14/08/2022 | Los Angeles FC | - | Charlotte FC | 5:0 | ||||
| 7. Round | 18/08/2022 | New York City FC | - | Charlotte FC | 1:3 | ||||
| 7. Round | 22/08/2022 | Charlotte FC | - | Orlando City | 1:2 | ||||
| 7. Round | 28/08/2022 | Charlotte FC | - | Toronto FC | 0:2 | ||||
| 8. Round | 04/09/2022 | FC Cincinnati | - | Charlotte FC | 2:0 | ||||
| 8. Round | 10/09/2022 | Charlotte FC | - | New York City FC | 1:0 | ||||
| 8. Round | 18/09/2022 | Chicago Fire | - | Charlotte FC | 2:3 | ||||
| 9. Round | 01/10/2022 | Charlotte FC | - | Philadelphia Union | 4:0 | ||||
| 9. Round | 09/10/2022 | New York RB | - | Charlotte FC | 2:0 |
Colombia