| 3. Round | 24/05/2012 | Seattle Sounders | - | Columbus Crew | 0:2 | ||||
| 3. Round | 27/05/2012 | Columbus Crew | - | Chicago Fire | 2:1 | ||||
| 4. Round | 17/06/2012 | New England Revolution | - | Columbus Crew | 0:0 | ||||
| 4. Round | 24/06/2012 | Chicago Fire | - | Columbus Crew | 2:1 |  |
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| 4. Round | 01/07/2012 | Columbus Crew | - | Real Salt Lake | 2:0 | |
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| 5. Round | 09/07/2012 | Impact de Montréal | - | Columbus Crew | 2:1 | ||||
| 8. Round | 28/10/2012 | Columbus Crew | - | Toronto FC | 2:1 |
Trinidad & Tobago