| Quarter-finals | 12/05/2022 | Atlético San Luis | - | CF Pachuca | 2:2 |  |
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| Quarter-finals | 15/05/2022 | CF Pachuca | - | Atlético San Luis | 3:2 | ||||
| Semi-finals | 20/05/2022 | CF América | - | CF Pachuca | 1:1 | ||||
| Semi-finals | 23/05/2022 | CF Pachuca | - | CF América | 3:0 | ||||
| Final | 27/05/2022 | Atlas Guadalajara | - | CF Pachuca | 2:0 | ||||
| Final | 30/05/2022 | CF Pachuca | - | Atlas Guadalajara | 2:1 | |
Mexico