| 3. Round | 08/08/2020 | CF Monterrey [U17] | - | Santos Laguna [U17] | 0:1 | ||||
| 4. Round | 13/08/2020 | CF América [U17] | - | Santos Laguna [U17] | 3:1 | ||||
| 5. Round | 16/08/2020 | Santos Laguna [U17] | - | Atlas Guadalajara [U17] | 2:4 |  |
 |
||
| 6. Round | 21/08/2020 | Club Necaxa [U17] | - | Santos Laguna [U17] | 2:1 | ||||
| 7. Round | 30/08/2020 | Santos Laguna [U17] | - | Gallos Blancos [U17] | 1:1 | |
|||
| 8. Round | 04/09/2020 | FC Juárez [U17] | - | Santos Laguna [U17] | 0:0 |  |
|||
| 12. Round | 27/09/2020 | Santos Laguna [U17] | - | Club Tijuana [U17] | 0:3 | ||||
| 13. Round | 02/10/2020 | Puebla FC [U17] | - | Santos Laguna [U17] | 2:0 | ||||
| 14. Round | 18/10/2020 | Santos Laguna [U17] | - | CF Pachuca [U17] | 1:3 | ||||
| 15. Round | 25/10/2020 | Santos Laguna [U17] | - | Atlético San Luis [U17] | 4:3 | ||||
| 2. Round | 13/11/2020 | Santos Laguna [U17] | - | Deportivo Guadalajara [U17] | 0:3 |
Mexico