| 5. Round | 17/08/2021 | FC Fredericia | - | Esbjerg fB | 1:0 |  |
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| 6. Round | 20/08/2021 | Esbjerg fB | - | Hvidovre IF | 1:2 | ||||
| 7. Round | 27/08/2021 | Nykøbing FC | - | Esbjerg fB | 1:1 | ||||
| 18. Round | 02/12/2021 | Hvidovre IF | - | Esbjerg fB | 2:0 | ||||
| 20. Round | 06/03/2022 | Vendsyssel FF | - | Esbjerg fB | 1:0 | ||||
| 21. Round | 13/03/2022 | AC Horsens | - | Esbjerg fB | 0:0 | ||||
| 22. Round | 18/03/2022 | Esbjerg fB | - | Lyngby BK | 0:3 |
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