| 2. Round | 13/01/2019 | Club Necaxa | - | Pumas UNAM | 2:1 | ||||
| 3. Round | 20/01/2019 | Pumas UNAM | - | Atlas Guadalajara | 2:2 | ||||
| 5. Round | 03/02/2019 | Pumas UNAM | - | CF Monterrey | 1:1 | ||||
| 6. Round | 09/02/2019 | Gallos Blancos | - | Pumas UNAM | 0:2 | ||||
| 7. Round | 17/02/2019 | Pumas UNAM | - | CF América | 1:0 | ||||
| 8. Round | 24/02/2019 | Pumas UNAM | - | Club León | 1:3 | ||||
| 9. Round | 03/03/2019 | Lobos BUAP | - | Pumas UNAM | 2:1 |  |
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| 10. Round | 10/03/2019 | Pumas UNAM | - | Monarcas Morelia | 2:2 | ||||
| 12. Round | 31/03/2019 | Pumas UNAM | - | Deportivo Guadalajara | 2:1 | ||||
| 13. Round | 07/04/2019 | UANL Tigres | - | Pumas UNAM | 2:0 | ||||
| 14. Round | 14/04/2019 | Pumas UNAM | - | Club Tijuana | 1:0 | ||||
| 15. Round | 21/04/2019 | Cruz Azul | - | Pumas UNAM | 2:1 |  |
Mexico