| 3. Round | 23/01/2021 | Atlas Guadalajara [U20] | - | UANL Tigres [U20] | 0:0 | ||||
| 4. Round | 30/01/2021 | Pumas UNAM [U20] | - | Atlas Guadalajara [U20] | 0:2 |  |
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| 5. Round | 06/02/2021 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 6. Round | 15/02/2021 | CF Pachuca [U20] | - | Atlas Guadalajara [U20] | 3:0 | ||||
| 7. Round | 20/02/2021 | Atlas Guadalajara [U20] | - | CF América [U20] | 2:1 | ||||
| 9. Round | 02/03/2021 | Atlas Guadalajara [U20] | - | Atlético San Luis [U20] | 2:0 | ||||
| 11. Round | 12/03/2021 | Puebla FC [U20] | - | Atlas Guadalajara [U20] | 0:5 | ||||
| 12. Round | 20/03/2021 | Cruz Azul [U20] | - | Atlas Guadalajara [U20] | 0:4 | ||||
| 17. Round | 30/04/2021 | Club Necaxa [U20] | - | Atlas Guadalajara [U20] | 2:2 | |
Mexico