| 1. Round | 03/03/2018 | Houston Dynamo | - | Atlanta United FC | 4:0 | ||||
| 1. Round | 10/03/2018 | Houston Dynamo | - | Vancouver Whitecaps | 1:2 | ||||
| 1. Round | 17/03/2018 | D.C. United | - | Houston Dynamo | 2:2 | ||||
| 3. Round | 31/05/2018 | Real Salt Lake | - | Houston Dynamo | 2:1 | ||||
| 4. Round | 03/06/2018 | Impact de Montréal | - | Houston Dynamo | 1:0 | ||||
| 5. Round | 15/07/2018 | Colorado Rapids | - | Houston Dynamo | 0:0 | ||||
| 6. Round | 12/08/2018 | Columbus Crew | - | Houston Dynamo | 1:0 | ||||
| 6. Round | 30/08/2018 | New York RB | - | Houston Dynamo | 1:0 | ||||
| 7. Round | 16/09/2018 | Houston Dynamo | - | Portland Timbers | 4:1 | ||||
| 7. Round | 23/09/2018 | Orlando City | - | Houston Dynamo | 0:0 | ||||
| 7. Round | 30/09/2018 | Houston Dynamo | - | San Jose Earthquakes | 3:2 | ||||
| 8. Round | 09/10/2018 | Seattle Sounders | - | Houston Dynamo | 4:1 | ||||
| 8. Round | 13/10/2018 | Los Angeles FC | - | Houston Dynamo | 4:2 | ||||
| 8. Round | 21/10/2018 | Houston Dynamo | - | Seattle Sounders | 2:3 |  |
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| 8. Round | 28/10/2018 | Los Angeles Galaxy | - | Houston Dynamo | 2:3 |
USA