11. Round | 19/03/2022 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 2:1 | ||||
12. Round | 26/03/2022 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 3:1 | ||||
13. Round | 02/04/2022 | CF Monterrey [U16] | - | Santos Laguna [U16] | 2:1 | ||||
17. Round | 30/04/2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 3:0 | ||||
18. Round | 07/05/2022 | Santos Laguna [U16] | - | Club León [U16] | 2:1 |