| 3. Round | 22/01/2022 | Club Tijuana [] | - | Atlético San Luis [] | 5:0 | ||||
| 6. Round | 12/02/2022 | Mazatlán FC [] | - | Club Tijuana [] | 1:3 | ||||
| 9. Round | 05/03/2022 | Santos Laguna [] | - | Club Tijuana [] | 2:1 | ||||
| 11. Round | 19/03/2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 3:0 | ||||
| 12. Round | 26/03/2022 | Club Tijuana [] | - | UANL Tigres [] | 3:1 | ||||
| 13. Round | 02/04/2022 | Club Tijuana [] | - | Atlas Guadalajara [] | 0:1 | ||||
| 14. Round | 05/04/2022 | Atlético San Luis [] | - | Club Tijuana [] | 0:3 | ||||
| 15. Round | 20/04/2022 | Club Tijuana [] | - | Santos Laguna [] | 4:1 | ||||
| 16. Round | 23/04/2022 | Club León [] | - | Club Tijuana [] | 2:1 | ||||
| 17. Round | 30/04/2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 | ||||
| 18. Round | 07/05/2022 | CF Monterrey [] | - | Club Tijuana [] | 1:0 |  |
USA