| 2. Round | 15/02/2022 | Atlético Tucumán II | - | Platense II | 3:1 | ||||
| 3. Round | 19/02/2022 | Unión de Santa Fe II | - | Atlético Tucumán II | 1:0 | ||||
| 4. Round | 25/02/2022 | Atlético Tucumán II | - | Patronato de Paraná II | 4:1 |  |
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| 6. Round | 14/03/2022 | Atlético Tucumán II | - | Racing Club II | 2:6 | ||||
| 7. Round | 21/03/2022 | Atlético Tucumán II | - | Central Córdoba SdE II | 2:2 | ||||
| 11. Round | 21/04/2022 | Atlético Tucumán II | - | Argentinos Juniors II | 2:1 | ||||
| 13. Round | 30/04/2022 | Atlético Tucumán II | - | Talleres de Córdoba II | 0:2 | ||||
| 14. Round | 06/05/2022 | Banfield II | - | Atlético Tucumán II | 3:4 |
Argentina