| 5. Round | 06/08/2021 | Gimnasia de La Plata II | - | Atlético Tucumán II | 1:0 | ||||
| 6. Round | 14/08/2021 | Atlético Tucumán II | - | Aldosivi II | 3:2 | ||||
| 7. Round | 20/08/2021 | Sarmiento de Junín II | - | Atlético Tucumán II | 3:1 | ||||
| 8. Round | 24/08/2021 | Atlético Tucumán II | - | Independiente II | 0:0 | ||||
| 11. Round | 10/09/2021 | Central Córdoba SdE II | - | Atlético Tucumán II | 1:1 | ||||
| 12. Round | 18/09/2021 | Atlético Tucumán II | - | Boca Juniors II | 1:1 | ||||
| 13. Round | 24/09/2021 | Banfield II | - | Atlético Tucumán II | 1:0 | ||||
| 14. Round | 01/10/2021 | Atlético Tucumán II | - | San Lorenzo II | 1:1 | ||||
| 15. Round | 08/10/2021 | Talleres de Córdoba II | - | Atlético Tucumán II | 1:1 |  |
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| 18. Round | 25/10/2021 | Atlético Tucumán II | - | Patronato de Paraná II | 0:1 | ||||
| 21. Round | 20/11/2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 |
Argentina