| 6. Round | 21/04/2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:0 | ||||
| 9. Round | 19/05/2021 | Gualaceo SC | - | América de Quito | 1:1 | ||||
| 10. Round | 26/05/2021 | Atlético Porteño | - | Gualaceo SC | 3:1 | ||||
| 11. Round | 02/06/2021 | Gualaceo SC | - | Chacaritas FC | 0:0 | ||||
| 16. Round | 20/06/2021 | Gualaceo SC | - | Liga de Portoviejo | 0:0 |
Ecuador