| 1. Round | 08/08/2021 | Union Titus Pétange | - | UNA Strassen | 1:2 | ||||
| 2. Round | 15/08/2021 | Swift Hesperange | - | Union Titus Pétange | 0:2 | ||||
| 3. Round | 23/08/2021 | Union Titus Pétange | - | FC Rodange 91 | 3:0 | ||||
| 4. Round | 29/08/2021 | RM Hamm Benfica | - | Union Titus Pétange | 0:3 | ||||
| 6. Round | 18/09/2021 | F91 Dudelange | - | Union Titus Pétange | 3:1 | ||||
| 7. Round | 22/09/2021 | Union Titus Pétange | - | Jeunesse Esch | 0:1 |  |
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| 8. Round | 26/09/2021 | US Hostert | - | Union Titus Pétange | 0:1 | ||||
| 9. Round | 17/10/2021 | Union Titus Pétange | - | RFCU Luxemburg | 4:2 | |
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| 10. Round | 23/10/2021 | Progrès Niedercorn | - | Union Titus Pétange | 3:2 | |
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| 11. Round | 07/11/2021 | US Mondorf | - | Union Titus Pétange | 2:1 | |
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| 21. Round | 13/03/2022 | Jeunesse Esch | - | Union Titus Pétange | 1:0 | ||||
| 28. Round | 06/05/2022 | Victoria Rosport | - | Union Titus Pétange | 1:1 | ||||
| 29. Round | 15/05/2022 | Union Titus Pétange | - | CS FOLA Esch | 0:1 | ||||
| 30. Round | 22/05/2022 | UNA Strassen | - | Union Titus Pétange | 2:2 | |
Luxembourg