| 1. Round | 18/09/2020 | Inter Playa | - | Cafessa Jalisco | 2:1 |  |
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| 2. Round | 27/09/2020 | Cafessa Jalisco | - | Cafetaleros de Chiapas | 3:3 | |
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| 6. Round | 25/10/2020 | Cafessa Jalisco | - | Club Irapuato | 4:3 | ||||
| 7. Round | 02/11/2020 | Club de Ciervos | - | Cafessa Jalisco | 0:5 | ||||
| 8. Round | 08/11/2020 | Cafessa Jalisco | - | Cañoneros Marina | 1:0 | ||||
| 9. Round | 15/11/2020 | Cruz Azul Hidalgo | - | Cafessa Jalisco | 0:1 | ||||
| 10. Round | 22/11/2020 | Cafessa Jalisco | - | CD Cuautla | 2:2 | ||||
| 11. Round | 29/11/2020 | Deportivo Dongu | - | Cafessa Jalisco | 0:1 | ||||
| 12. Round | 06/12/2020 | Cafessa Jalisco | - | Aguacateros CDU | 4:1 | ||||
| 19. Round | 19/02/2021 | Club Irapuato | - | Cafessa Jalisco | 0:0 | |
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| 20. Round | 28/02/2021 | Cafessa Jalisco | - | Club de Ciervos | 3:0 | ||||
| 21. Round | 05/03/2021 | Cañoneros Marina | - | Cafessa Jalisco | 2:3 | ||||
| 23. Round | 21/03/2021 | CD Cuautla | - | Cafessa Jalisco | 0:2 | ||||
| 24. Round | 01/04/2021 | Cafessa Jalisco | - | Deportivo Dongu | 1:0 | ||||
| 25. Round | 03/04/2021 | Aguacateros CDU | - | Cafessa Jalisco | 1:0 | ||||
| 26. Round | 10/04/2021 | Cafessa Jalisco | - | Pioneros de Cancún | 0:0 |
Mexico