| 8. Round | 30/05/2021 | Santa Cruz | - | Deportes Iquique | 1:3 |  |
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| 9. Round | 06/06/2021 | Deportes Iquique | - | Universidad de Concepción | 5:1 | ||||
| 10. Round | 09/07/2021 | Cobreloa | - | Deportes Iquique | 3:2 | ||||
| 12. Round | 24/07/2021 | Deportes Iquique | - | Santiago Morning | 1:2 | ||||
| 2. Round | 29/07/2021 | Fernández Vial | - | Deportes Iquique | 0:1 | ||||
| 14. Round | 07/08/2021 | Deportes Iquique | - | Deportes Temuco | 2:2 | ||||
| 15. Round | 15/08/2021 | Puerto Montt | - | Deportes Iquique | 0:0 | ||||
| 16. Round | 24/08/2021 | Coquimbo Unido | - | Deportes Iquique | 3:1 | ||||
| 26. Round | 20/10/2021 | Deportes Iquique | - | Unión San Felipe | 1:0 | ||||
| 27. Round | 25/10/2021 | Santiago Morning | - | Deportes Iquique | 1:0 | ||||
| 28. Round | 01/11/2021 | Deportes Iquique | - | Rangers | 2:2 | ||||
| 29. Round | 06/11/2021 | Deportes Temuco | - | Deportes Iquique | 2:1 |
Chile