1. Round | 03/06/2021 | Defensor Sporting | - | Rocha | 2:1 | ||||
2. Round | 10/06/2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
3. Round | 16/06/2021 | Albion | - | Defensor Sporting | 2:2 | ||||
6. Round | 09/07/2021 | Defensor Sporting | - | Racing | 1:4 | ||||
7. Round | 15/07/2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
8. Round | 22/07/2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
9. Round | 28/07/2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | ||||
10. Round | 05/08/2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
11. Round | 14/08/2021 | Danubio | - | Defensor Sporting | 0:1 | ||||
12. Round | 16/09/2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
19. Round | 02/11/2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 | ||||
20. Round | 10/11/2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | ||||
21. Round | 18/11/2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
22. Round | 24/11/2021 | Defensor Sporting | - | Danubio | 0:1 |