| 4. Round | 11/09/2021 | 1. FC Union Berlin | - | FC Augsburg | 0:0 | ||||
| 7. Round | 03/10/2021 | 1. FSV Mainz 05 | - | 1. FC Union Berlin | 1:2 | ||||
| 9. Round | 24/10/2021 | VfB Stuttgart | - | 1. FC Union Berlin | 1:1 | ||||
| 10. Round | 30/10/2021 | 1. FC Union Berlin | - | Bayern München | 2:5 | ||||
| 12. Round | 20/11/2021 | 1. FC Union Berlin | - | Hertha BSC | 2:0 | ||||
| 16. Round | 15/12/2021 | 1. FC Union Berlin | - | SC Freiburg | 0:0 | ||||
| 17. Round | 18/12/2021 | VfL Bochum | - | 1. FC Union Berlin | 0:1 | ||||
| 18. Round | 08/01/2022 | Bayer Leverkusen | - | 1. FC Union Berlin | 2:2 | ||||
| 20. Round | 22/01/2022 | Bor. Mönchengladbach | - | 1. FC Union Berlin | 1:2 | ||||
| 22. Round | 13/02/2022 | 1. FC Union Berlin | - | Borussia Dortmund | 0:3 |  |
|||
| 23. Round | 19/02/2022 | Arminia Bielefeld | - | 1. FC Union Berlin | 1:0 | ||||
| 24. Round | 26/02/2022 | 1. FC Union Berlin | - | 1. FSV Mainz 05 | 3:1 | ||||
| 25. Round | 05/03/2022 | VfL Wolfsburg | - | 1. FC Union Berlin | 1:0 | |
|||
| 26. Round | 12/03/2022 | 1. FC Union Berlin | - | VfB Stuttgart | 1:1 | ||||
| 27. Round | 19/03/2022 | Bayern München | - | 1. FC Union Berlin | 4:0 | ||||
| 28. Round | 01/04/2022 | 1. FC Union Berlin | - | 1. FC Köln | 1:0 |
Germany