| 5. Round | 19/06/2022 | Columbus Crew | - | Charlotte FC | 1:1 | ||||
| 6. Round | 04/07/2022 | Columbus Crew | - | Philadelphia Union | 0:0 | ||||
| 6. Round | 24/07/2022 | Columbus Crew | - | New England Revolution | 0:0 | ||||
| 7. Round | 04/08/2022 | Columbus Crew | - | CF Montréal | 1:2 | ||||
| 7. Round | 21/08/2022 | Columbus Crew | - | Atlanta United FC | 2:2 | ||||
| 7. Round | 28/08/2022 | FC Cincinnati | - | Columbus Crew | 2:2 | ||||
| 8. Round | 03/09/2022 | Columbus Crew | - | Chicago Fire | 0:0 | ||||
| 8. Round | 14/09/2022 | Inter Miami CF | - | Columbus Crew | 2:1 | ||||
| 8. Round | 18/09/2022 | Columbus Crew | - | Portland Timbers | 1:1 |  |
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| 9. Round | 02/10/2022 | Columbus Crew | - | New York RB | 2:1 | ||||
| 9. Round | 09/10/2022 | Orlando City | - | Columbus Crew | 2:1 |
Trinidad & Tobago
