| 3. Round | 20/01/2023 | Mazatlán FC [U18] | - | Santos Laguna [U18] | 0:2 | ||||
| 4. Round | 26/01/2023 | Atlas Guadalajara [U18] | - | Santos Laguna [U18] | 1:0 | ||||
| 6. Round | 10/02/2023 | FC Juárez [U18] | - | Santos Laguna [U18] | 3:3 | ||||
| 8. Round | 18/02/2023 | Atlético San Luis [U18] | - | Santos Laguna [U18] | 3:4 | ||||
| 11. Round | 12/03/2023 | Santos Laguna [U18] | - | Club Tijuana [U18] | 3:0 | ||||
| 12. Round | 19/03/2023 | Club León [U18] | - | Santos Laguna [U18] | 4:1 | ||||
| 13. Round | 31/03/2023 | Club Necaxa [U18] | - | Santos Laguna [U18] | 4:1 | ||||
| 14. Round | 09/04/2023 | Santos Laguna [U18] | - | CF Pachuca [U18] | 2:0 | ||||
| 17. Round | 29/04/2023 | Cruz Azul [U18] | - | Santos Laguna [U18] | 2:0 |
Mexico