| 4. Round | 13/03/2022 | Universidad Catolica | - | Macará | 2:2 | ||||
| 5. Round | 20/03/2022 | Macará | - | Guayaquil City | 2:0 | ||||
| 6. Round | 05/04/2022 | Macará | - | Cumbayá | 0:0 | ||||
| 7. Round | 12/04/2022 | Aucas | - | Macará | 2:0 | ||||
| 8. Round | 17/04/2022 | Macará | - | Deportivo Cuenca | 0:1 | ||||
| 9. Round | 21/04/2022 | Mushuc Runa | - | Macará | 0:0 |  |
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| 10. Round | 25/04/2022 | Macará | - | Barcelona | 0:1 | |
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| 11. Round | 30/04/2022 | Gualaceo SC | - | Macará | 2:1 | ||||
| 12. Round | 10/05/2022 | Macará | - | Independiente del Valle | 0:1 |
Ecuador