| 1. Round | 20/02/2022 | Guayaquil City | - | Deportivo Cuenca | 3:0 dec. |  |
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| 2. Round | 26/02/2022 | Universidad Catolica | - | Guayaquil City | 1:1 | ||||
| 3. Round | 05/03/2022 | Emelec | - | Guayaquil City | 2:2 | ||||
| 4. Round | 15/03/2022 | Guayaquil City | - | Delfín SC | 1:1 |  |
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| 5. Round | 20/03/2022 | Macará | - | Guayaquil City | 2:0 | ||||
| 6. Round | 03/04/2022 | Guayaquil City | - | Técnico Universitario | 0:1 | |
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| 7. Round | 10/04/2022 | Independiente del Valle | - | Guayaquil City | 0:0 | ||||
| 8. Round | 16/04/2022 | Guayaquil City | - | Aucas | 4:0 | ||||
| 10. Round | 26/04/2022 | Guayaquil City | - | Cumbayá | 4:1 | |
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| 11. Round | 30/04/2022 | Mushuc Runa | - | Guayaquil City | 2:0 | ||||
| 12. Round | 09/05/2022 | Guayaquil City | - | Barcelona | 1:4 | ||||
| 9. Round | 11/05/2022 | 9 de Octubre | - | Guayaquil City | 2:2 | |
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| 13. Round | 17/05/2022 | Gualaceo SC | - | Guayaquil City | 2:1 | ||||
| 14. Round | 22/05/2022 | Guayaquil City | - | LDU Quito | 2:2 |
Ecuador