| 20. Round | 07/02/2021 | Karlsruher SC | - | Jahn Regensburg | 0:0 | ||||
| 21. Round | 13/02/2021 | SV Sandhausen | - | Karlsruher SC | 2:3 |  |
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| 26. Round | 19/03/2021 | SC Paderborn 07 | - | Karlsruher SC | 2:2 | ||||
| 27. Round | 03/04/2021 | Karlsruher SC | - | VfL Osnabrück | 0:1 | |
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| 31. Round | 23/04/2021 | Karlsruher SC | - | Würzburger Kickers | 2:2 | ||||
| 29. Round | 26/04/2021 | Karlsruher SC | - | Erzgebirge Aue | 0:0 | |
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| 30. Round | 29/04/2021 | Hamburger SV | - | Karlsruher SC | 1:1 | ||||
| 28. Round | 03/05/2021 | Fortuna Düsseldorf | - | Karlsruher SC | 3:2 | ||||
| 32. Round | 08/05/2021 | SpVgg Greuther Fürth | - | Karlsruher SC | 2:2 | ||||
| 33. Round | 16/05/2021 | Karlsruher SC | - | Holstein Kiel | 3:2 |
Austria
