| 1. Round | 01/07/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 6:1 |  |
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| 5. Round | 26/07/2022 | Club León [U20] | - | Deportivo Toluca [U20] | 0:0 | ||||
| 6. Round | 29/07/2022 | FC Juárez [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 16. Round | 02/08/2022 | Deportivo Toluca [U20] | - | Puebla FC [U20] | 1:2 | ||||
| 7. Round | 07/08/2022 | Deportivo Toluca [U20] | - | Club Tijuana [U20] | 2:2 | ||||
| 10. Round | 21/08/2022 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 5:0 | ||||
| 11. Round | 28/08/2022 | Deportivo Toluca [U20] | - | CF Pachuca [U20] | 2:3 | ||||
| 13. Round | 07/09/2022 | UANL Tigres [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 14. Round | 10/09/2022 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 1:2 | ||||
| 15. Round | 16/09/2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 4. Round | 22/09/2022 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 17. Round | 02/10/2022 | Deportivo Toluca [U20] | - | Gallos Blancos [U20] | 2:2 |
Mexico