| 11. Round | 22/09/2021 | FC Sheriff | - | FC Floreşti | 4:0 | ||||
| 12. Round | 25/09/2021 | Dinamo-Auto | - | FC Sheriff | 0:7 | ||||
| 13. Round | 02/10/2021 | FC Milsami | - | FC Sheriff | 0:1 | ||||
| 14. Round | 16/10/2021 | FC Sheriff | - | FC Sfîntul Gheorghe | 4:0 | ||||
| 15. Round | 23/10/2021 | FC Sheriff | - | FC Bălţi | 2:0 |  |
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| 16. Round | 31/10/2021 | CS Petrocub | - | FC Sheriff | 0:2 | |
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| 17. Round | 06/11/2021 | FC Sheriff | - | FC Zimbru | 6:0 | |
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| 18. Round | 20/11/2021 | FC Floreşti | - | FC Sheriff | 1:3 | |
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| 19. Round | 28/11/2021 | FC Sheriff | - | Dinamo-Auto | 7:0 | |
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| 2. Round | 02/12/2021 | CS Petrocub | - | FC Sheriff | 0:0 | ||||
| 3. Round | 11/12/2021 | FC Sheriff | - | FC Zimbru | 4:0 | ||||
| 6. Round | 01/03/2022 | FC Sheriff | - | FC Milsami | 1:0 | ||||
| 7. Round | 05/03/2022 | FC Sheriff | - | FC Sfîntul Gheorghe | 2:0 | ||||
| 20. Round | 13/03/2022 | FC Sheriff | - | FC Milsami | 0:1 |  |
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| 24. Round | 16/04/2022 | FC Zimbru | - | FC Sheriff | 1:1 |
Ghana