| 1. Round | 06/05/2021 | Guayaquil City [Women] | - | Emelec [Women] | 1:0 |  |
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| 2. Round | 12/05/2021 | LDJ [Women] | - | Guayaquil City [Women] | 1:1 | ||||
| 3. Round | 17/05/2021 | Guayaquil City [Women] | - | Deportivo Cuenca [Women] | 1:8 | |
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| 4. Round | 22/05/2021 | Barcelona [Women] | - | Guayaquil City [Women] | 5:0 | ||||
| 5. Round | 28/05/2021 | Guayaquil City [Women] | - | Técnico Universitario [Women] | 0:1 | ||||
| 6. Round | 04/06/2021 | Guayaquil City [Women] | - | Macará [Women] | 1:0 | ||||
| 7. Round | 14/06/2021 | UPS Carneras [Women] | - | Guayaquil City [Women] | 2:1 | ||||
| 8. Round | 19/06/2021 | Emelec [Women] | - | Guayaquil City [Women] | 2:0 | |
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| 9. Round | 25/06/2021 | Guayaquil City [Women] | - | LDJ [Women] | 0:0 | ||||
| 10. Round | 02/07/2021 | Deportivo Cuenca [Women] | - | Guayaquil City [Women] | 7:0 | ||||
| 12. Round | 18/07/2021 | Técnico Universitario [Women] | - | Guayaquil City [Women] | 0:1 | ||||
| 13. Round | 25/07/2021 | Macará [Women] | - | Guayaquil City [Women] | 2:1 | ||||
| 14. Round | 01/08/2021 | Guayaquil City [Women] | - | UPS Carneras [Women] | 0:4 |
Ecuador