| 3. Round | 01/08/2021 | Zenit St. Petersburg 2 | - | Zvezda St. Petersburg | 2:1 | ||||
| 4. Round | 07/08/2021 | Dinamo St. Petersburg | - | Zenit St. Petersburg 2 | 2:0 | ||||
| 5. Round | 15/08/2021 | Zenit St. Petersburg 2 | - | FK Kairat Moskva | 1:2 | ||||
| 6. Round | 21/08/2021 | FK Krasava | - | Zenit St. Petersburg 2 | 6:0 | ||||
| 11. Round | 18/09/2021 | Zenit St. Petersburg 2 | - | Baltika Kaliningrad 2 | 2:1 | ||||
| 14. Round | 04/10/2021 | Zenit St. Petersburg 2 | - | Dinamo St. Petersburg | 1:2 |  |
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| 15. Round | 10/10/2021 | FK Kairat Moskva | - | Zenit St. Petersburg 2 | 3:0 | ||||
| 17. Round | 19/10/2021 | FK Chita | - | Zenit St. Petersburg 2 | 1:0 | ||||
| 21. Round | 10/11/2021 | Baltika Kaliningrad 2 | - | Zenit St. Petersburg 2 | 2:1 | ||||
| 22. Round | 14/11/2021 | Zenit St. Petersburg 2 | - | Luki-Energiya Velikiye Luki | 5:3 |  |
Russia