| 2. Round | 24/07/2021 | FK Tver | - | FK Chita | 1:1 | ||||
| 4. Round | 07/08/2021 | FK Tver | - | FK Leningradets | 3:0 | ||||
| 6. Round | 21/08/2021 | FK Tver | - | Baltika Kaliningrad 2 | 1:0 |  |
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| 7. Round | 29/08/2021 | FK Tver | - | Luki-Energiya Velikiye Luki | 3:0 | ||||
| 8. Round | 04/09/2021 | FK Tver | - | Zenit St. Petersburg 2 | 2:2 |  |
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| 9. Round | 10/09/2021 | Zvezda St. Petersburg | - | FK Tver | 1:2 | |
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| 10. Round | 14/09/2021 | FK Tver | - | Dinamo St. Petersburg | 0:0 | |
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| 11. Round | 18/09/2021 | FK Kairat Moskva | - | FK Tver | 0:6 | ||||
| 12. Round | 26/09/2021 | FK Chita | - | FK Tver | 0:2 | ||||
| 14. Round | 04/10/2021 | FK Leningradets | - | FK Tver | 6:1 | ||||
| 16. Round | 14/10/2021 | Baltika Kaliningrad 2 | - | FK Tver | 1:2 | ||||
| 18. Round | 25/10/2021 | Zenit St. Petersburg 2 | - | FK Tver | 1:1 | ||||
| 19. Round | 31/10/2021 | FK Tver | - | Zvezda St. Petersburg | 1:0 | |
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| 20. Round | 05/11/2021 | Dinamo St. Petersburg | - | FK Tver | 1:2 | ||||
| 21. Round | 10/11/2021 | FK Tver | - | FK Kairat Moskva | 3:0 | ||||
| 22. Round | 14/11/2021 | FK Krasava | - | FK Tver | 0:0 | |
Russia