| 1. Round | 28/07/2000 | Olympique Marseille | - | ESTAC Troyes | 3:1 | ||||
| 2. Round | 04/08/2000 | AS Saint-Étienne | - | Olympique Marseille | 3:0 |  |
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| 3. Round | 13/08/2000 | Olympique Marseille | - | RC Lens | 0:0 | ||||
| 4. Round | 19/08/2000 | FC Nantes | - | Olympique Marseille | 3:2 | |
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| 5. Round | 26/08/2000 | Olympique Marseille | - | EA Guingamp | 3:1 | |
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| 7. Round | 10/09/2000 | Toulouse FC | - | Olympique Marseille | 2:0 | ||||
| 15. Round | 11/11/2000 | CS Sedan | - | Olympique Marseille | 2:0 | ||||
| 16. Round | 17/11/2000 | Olympique Marseille | - | FC Metz | 4:1 | ||||
| 17. Round | 25/11/2000 | SC Bastia | - | Olympique Marseille | 3:0 | ||||
| 18. Round | 29/11/2000 | Olympique Marseille | - | AS Saint-Étienne | 2:1 | ||||
| 19. Round | 03/12/2000 | RC Lens | - | Olympique Marseille | 1:0 | ||||
| 21. Round | 16/12/2000 | EA Guingamp | - | Olympique Marseille | 1:0 | ||||
| 22. Round | 20/12/2000 | Olympique Marseille | - | AS Monaco | 2:1 | |
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