| 1. Round | 28/08/2021 | Hellas Verona [Youth] | - | Empoli FC [Youth] | 2:1 | ||||
| 2. Round | 12/09/2021 | Delfino Pescara [Youth] | - | Empoli FC [Youth] | 0:0 | ||||
| 4. Round | 25/09/2021 | Torino FC [Youth] | - | Empoli FC [Youth] | 1:2 | ||||
| 5. Round | 16/10/2021 | Empoli FC [Youth] | - | Inter [Youth] | 1:1 | ||||
| 6. Round | 24/10/2021 | AS Roma [Youth] | - | Empoli FC [Youth] | 2:2 | ||||
| 7. Round | 31/10/2021 | Empoli FC [Youth] | - | SSC Napoli [Youth] | 1:0 | ||||
| 8. Round | 07/11/2021 | US Lecce [Youth] | - | Empoli FC [Youth] | 0:0 | ||||
| 9. Round | 20/11/2021 | Empoli FC [Youth] | - | ACF Fiorentina [Youth] | 2:0 | ||||
| 10. Round | 28/11/2021 | Sampdoria [Youth] | - | Empoli FC [Youth] | 2:0 | ||||
| 11. Round | 05/12/2021 | Empoli FC [Youth] | - | Atalanta [Youth] | 1:1 | ||||
| 13. Round | 17/12/2021 | Empoli FC [Youth] | - | Juventus [Youth] | 1:2 | ||||
| 14. Round | 21/12/2021 | Empoli FC [Youth] | - | Sassuolo Calcio [Youth] | 0:2 | ||||
| 34. Round | 15/05/2022 | Empoli FC [Youth] | - | Cagliari Calcio [Youth] | 1:0 |
Slovenia