| 1. Round | 16/01/2022 | Yalmakan FC | - | Inter Playa | 0:0 | ||||
| 2. Round | 22/01/2022 | Inter Playa | - | Cafetaleros de Chiapas | 0:0 | ||||
| 3. Round | 30/01/2022 | Lobos ULMX | - | Inter Playa | 1:4 | ||||
| 4. Round | 04/02/2022 | Inter Playa | - | CD Zap | 3:2 |  |
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| 5. Round | 13/02/2022 | Reboceros de La Piedad | - | Inter Playa | 2:0 | ||||
| 6. Round | 18/02/2022 | Inter Playa | - | Inter de Querétaro | 3:0 | |
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| 7. Round | 26/02/2022 | Deportivo Dongu | - | Inter Playa | 1:4 | |
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| 8. Round | 04/03/2022 | Inter Playa | - | Montañeses FC | 4:1 | |
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| 9. Round | 12/03/2022 | Cañoneros FC | - | Inter Playa | 0:1 | |
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| 10. Round | 18/03/2022 | Inter Playa | - | Leviatán FC | 4:0 | ||||
| 12. Round | 02/04/2022 | Sporting Canamy | - | Inter Playa | 1:2 | |
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| 13. Round | 08/04/2022 | Inter Playa | - | Escorpiones | 6:1 | |
Colombia