3. Round | 22/09/2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
4. Round | 27/09/2021 | PAS Giannina | - | OFI Heraklion | 1:1 | ||||
5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
6. Round | 17/10/2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
8. Round | 31/10/2021 | Panathinaikos | - | OFI Heraklion | 0:0 | ||||
14. Round | 16/12/2021 | OFI Heraklion | - | Aris Saloniki | 1:1 | ||||
15. Round | 20/12/2021 | AEK Athen | - | OFI Heraklion | 1:2 | ||||
16. Round | 04/01/2022 | Asteras Tripolis | - | OFI Heraklion | 1:0 | ||||
17. Round | 08/01/2022 | OFI Heraklion | - | PAS Giannina | 1:1 | ||||
13. Round | 12/01/2022 | Apollon Smyrnis | - | OFI Heraklion | 0:3 | ||||
18. Round | 15/01/2022 | PAOK Saloniki | - | OFI Heraklion | 3:0 | ||||
23. Round | 13/02/2022 | OFI Heraklion | - | Volos NFC | 2:1 | ||||
22. Round | 16/02/2022 | Atromitos | - | OFI Heraklion | 2:2 | ||||
24. Round | 19/02/2022 | Ionikos Nikea | - | OFI Heraklion | 0:0 | ||||
25. Round | 27/02/2022 | Olympiakos Piraeus | - | OFI Heraklion | 2:0 |