| 1. Round | 17/09/2000 | OFI Heraklion | - | Aris Saloniki | 2:3 | ||||
| 3. Round | 30/09/2000 | Panathinaikos | - | Aris Saloniki | 2:2 | ||||
| 4. Round | 31/10/2000 | Aris Saloniki | - | PAOK Saloniki | 4:0 | ||||
| 5. Round | 04/11/2000 | Skoda Xanthi | - | Aris Saloniki | 1:0 | ||||
| 6. Round | 11/11/2000 | Aris Saloniki | - | Iraklis Saloniki | 0:2 | ||||
| 9. Round | 02/12/2000 | Aris Saloniki | - | Ionikos Nikea | 0:0 |  |
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| 12. Round | 02/01/2001 | PS Kalamata | - | Aris Saloniki | 1:1 | |
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| 13. Round | 06/01/2001 | Aris Saloniki | - | PAS Giannina | 1:0 | ||||
| 14. Round | 13/01/2001 | Panionios GSS | - | Aris Saloniki | 2:0 | |
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| 28. Round | 05/05/2001 | PAS Giannina | - | Aris Saloniki | 2:1 | ||||
| 29. Round | 19/05/2001 | Aris Saloniki | - | Panionios GSS | 3:2 |
Greece