| 5. Round | 08/07/2012 | Real Salt Lake | - | Portland Timbers | 3:0 | ||||
| 5. Round | 15/07/2012 | Portland Timbers | - | Los Angeles Galaxy | 3:5 |  |
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| 5. Round | 18/07/2012 | CD Chivas | - | Portland Timbers | 1:0 |  |
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| 5. Round | 22/07/2012 | FC Dallas | - | Portland Timbers | 5:0 | ||||
| 5. Round | 29/07/2012 | Portland Timbers | - | CD Chivas | 0:1 | ||||
| 6. Round | 06/08/2012 | Portland Timbers | - | FC Dallas | 1:1 | ||||
| 6. Round | 16/08/2012 | Toronto FC | - | Portland Timbers | 2:2 | ||||
| 6. Round | 20/08/2012 | New York RB | - | Portland Timbers | 3:2 | ||||
| 6. Round | 26/08/2012 | Portland Timbers | - | Vancouver Whitecaps | 2:1 | ||||
| 6. Round | 01/09/2012 | Portland Timbers | - | Colorado Rapids | 1:0 | ||||
| 7. Round | 06/09/2012 | Colorado Rapids | - | Portland Timbers | 3:0 | ||||
| 7. Round | 15/09/2012 | Portland Timbers | - | Seattle Sounders | 1:1 | ||||
| 7. Round | 20/09/2012 | San Jose Earthquakes | - | Portland Timbers | 2:2 | ||||
| 7. Round | 23/09/2012 | Real Salt Lake | - | Portland Timbers | 2:1 | ||||
| 7. Round | 30/09/2012 | Portland Timbers | - | D.C. United | 1:1 | ||||
| 8. Round | 22/10/2012 | Vancouver Whitecaps | - | Portland Timbers | 0:1 | ||||
| 8. Round | 27/10/2012 | Portland Timbers | - | San Jose Earthquakes | 1:1 |
Japan