| 2. Round | 01/08/2021 | FK Senica | - | Spartak Trnava | 2:1 | ||||
| 3. Round | 06/08/2021 | Zlaté Moravce | - | FK Senica | 1:1 | ||||
| 4. Round | 14/08/2021 | FK Senica | - | FC DAC 1904 | 1:1 | ||||
| 5. Round | 22/08/2021 | MŠK Žilina | - | FK Senica | 3:0 | ||||
| 6. Round | 28/08/2021 | Tatran Liptovský Mikuláš | - | FK Senica | 1:2 | ||||
| 7. Round | 11/09/2021 | FK Senica | - | FK Pohronie | 1:0 | ||||
| 8. Round | 18/09/2021 | AS Trenčín | - | FK Senica | 3:3 | ||||
| 9. Round | 25/09/2021 | FK Senica | - | Slovan Bratislava | 0:3 | ||||
| 10. Round | 02/10/2021 | ŠKF Sereď | - | FK Senica | 2:1 | ||||
| 11. Round | 16/10/2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 12. Round | 23/10/2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
| 13. Round | 29/10/2021 | Spartak Trnava | - | FK Senica | 2:1 | ||||
| 14. Round | 06/11/2021 | FK Senica | - | Zlaté Moravce | 1:2 | ||||
| 15. Round | 20/11/2021 | FC DAC 1904 | - | FK Senica | 1:0 | ||||
| 16. Round | 30/11/2021 | FK Senica | - | MŠK Žilina | 2:2 | ||||
| 17. Round | 04/12/2021 | FK Senica | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 18. Round | 11/12/2021 | FK Pohronie | - | FK Senica | 0:1 | ||||
| 19. Round | 18/12/2021 | FK Senica | - | AS Trenčín | 1:0 |
Canada
Czech Republic