| 1. Round | 12/08/2005 | MVV | - | AGOVV | 2:2 | ||||
| 2. Round | 19/08/2005 | De Graafschap | - | MVV | 0:2 | ||||
| 6. Round | 02/09/2005 | FC Eindhoven | - | MVV | 1:1 | ||||
| 8. Round | 16/09/2005 | SBV Excelsior | - | MVV | 1:0 | ||||
| 9. Round | 23/09/2005 | MVV | - | VVV-Venlo | 2:0 | ||||
| 12. Round | 06/10/2005 | FC Emmen | - | MVV | 2:2 | ||||
| 13. Round | 14/10/2005 | MVV | - | Go Ahead Eagles | 1:0 | ||||
| 14. Round | 21/10/2005 | Stormvogels Telstar | - | MVV | 1:3 | ||||
| 16. Round | 04/11/2005 | FC Omniworld | - | MVV | 1:3 | ||||
| 18. Round | 18/11/2005 | FC Zwolle | - | MVV | 4:1 | ||||
| 19. Round | 25/11/2005 | MVV | - | HFC Haarlem | 1:2 | ||||
| 20. Round | 28/11/2005 | FC Volendam | - | MVV | 0:0 | ||||
| 22. Round | 09/12/2005 | AGOVV | - | MVV | 2:1 | ||||
| 24. Round | 23/12/2005 | BV Veendam | - | MVV | 3:3 | ||||
| 30. Round | 17/02/2006 | VVV-Venlo | - | MVV | 1:3 | ||||
| 32. Round | 03/03/2006 | SC Cambuur | - | MVV | 3:0 | ||||
| 34. Round | 13/03/2006 | Helmond Sport | - | MVV | 2:0 | ||||
| 38. Round | 07/04/2006 | HFC Haarlem | - | MVV | 0:0 |
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