| 14. Round | 16/01/2022 | OFI Ierapetra | - | Asteras Vlachioti | 3:1 | ||||
| 6. Round | 19/01/2022 | Asteras Vlachioti | - | PS Kalamata | 0:0 | ||||
| 15. Round | 23/01/2022 | Asteras Vlachioti | - | GS Kallithea | 0:2 | ||||
| 16. Round | 29/01/2022 | AO Egaleo | - | Asteras Vlachioti | 1:0 | ||||
| 11. Round | 02/02/2022 | Asteras Vlachioti | - | Diagoras FC | 2:0 | ||||
| 12. Round | 09/02/2022 | PAE Chania | - | Asteras Vlachioti | 3:1 |  |
|||
| 18. Round | 13/02/2022 | Asteras Vlachioti | - | Levadiakos | 1:2 |  |
|
||
| 19. Round | 16/02/2022 | AS Rhodos | - | Asteras Vlachioti | 0:1 | |
|||
| 20. Round | 20/02/2022 | Asteras Vlachioti | - | AO Episkopi | 0:0 | ||||
| 25. Round | 20/03/2022 | AE Karaiskakis | - | Asteras Vlachioti | 0:1 | |
|||
| 26. Round | 26/03/2022 | Asteras Vlachioti | - | Ergotelis | 4:0 |
Ghana