| 3. Round | 13/05/2018 | Rio Grande Valley FC | - | San Antonio FC | 0:0 | ||||
| 4. Round | 17/06/2018 | San Antonio FC | - | Sacramento Republic | 1:0 | ||||
| 4. Round | 01/07/2018 | Colorado Springs Switchbacks | - | San Antonio FC | 1:1 | ||||
| 5. Round | 15/07/2018 | Orange County SC | - | San Antonio FC | 3:0 | ||||
| 5. Round | 22/07/2018 | San Antonio FC | - | Real Monarchs SLC | 4:2 | ||||
| 5. Round | 26/07/2018 | San Antonio FC | - | Colorado Springs Switchbacks | 1:0 |  |
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| 5. Round | 29/07/2018 | OKC Energy FC | - | San Antonio FC | 1:2 | ||||
| 6. Round | 05/08/2018 | San Antonio FC | - | Los Angeles Galaxy II | 2:1 | ||||
| 6. Round | 12/08/2018 | Seattle Sounders 2 | - | San Antonio FC | 3:2 | ||||
| 6. Round | 16/08/2018 | Portland Timbers 2 | - | San Antonio FC | 2:1 | ||||
| 6. Round | 23/08/2018 | Phoenix Rising | - | San Antonio FC | 4:0 | ||||
| 6. Round | 26/08/2018 | San Antonio FC | - | Swope Park Rangers | 1:2 | ||||
| 7. Round | 04/09/2018 | Real Monarchs SLC | - | San Antonio FC | 1:2 | ||||
| 7. Round | 09/09/2018 | San Antonio FC | - | Phoenix Rising | 3:2 |  |
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| 7. Round | 23/09/2018 | Saint Louis FC | - | San Antonio FC | 2:0 | ||||
| 7. Round | 30/09/2018 | San Antonio FC | - | Seattle Sounders 2 | 3:1 |
USA