| 1. Round | 21/08/2010 | Hamburger SV | - | FC Schalke 04 | 2:1 | ||||
| 2. Round | 28/08/2010 | FC Schalke 04 | - | Hannover 96 | 1:2 | ||||
| 7. Round | 02/10/2010 | 1. FC Nürnberg | - | FC Schalke 04 | 2:1 | ||||
| 15. Round | 04/12/2010 | FC Schalke 04 | - | Bayern München | 2:0 | ||||
| 16. Round | 12/12/2010 | 1. FSV Mainz 05 | - | FC Schalke 04 | 0:1 | ||||
| 17. Round | 18/12/2010 | FC Schalke 04 | - | 1. FC Köln | 3:0 | ||||
| 19. Round | 22/01/2011 | Hannover 96 | - | FC Schalke 04 | 0:1 | ||||
| 20. Round | 29/01/2011 | FC Schalke 04 | - | 1899 Hoffenheim | 0:1 | ||||
| 21. Round | 04/02/2011 | Borussia Dortmund | - | FC Schalke 04 | 0:0 | ||||
| 25. Round | 05/03/2011 | VfB Stuttgart | - | FC Schalke 04 | 1:0 |  |
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| 26. Round | 12/03/2011 | FC Schalke 04 | - | Eintracht Frankfurt | 2:1 | ||||
| 27. Round | 20/03/2011 | Bayer Leverkusen | - | FC Schalke 04 | 2:0 | ||||
| 28. Round | 01/04/2011 | FC St. Pauli | - | FC Schalke 04 | 0:2 | |
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| 29. Round | 09/04/2011 | FC Schalke 04 | - | VfL Wolfsburg | 1:0 | ||||
| 30. Round | 16/04/2011 | Werder Bremen | - | FC Schalke 04 | 1:1 | |
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| 32. Round | 30/04/2011 | Bayern München | - | FC Schalke 04 | 4:1 | ||||
| 33. Round | 07/05/2011 | FC Schalke 04 | - | 1. FSV Mainz 05 | 1:3 | |
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| 34. Round | 14/05/2011 | 1. FC Köln | - | FC Schalke 04 | 2:1 | |
Greece
