| 5. Round | 12/08/2021 | Atlanta United II | - | OKC Energy FC | 2:2 | ||||
| 5. Round | 15/08/2021 | Indy Eleven | - | OKC Energy FC | 2:1 |  |
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| 5. Round | 22/08/2021 | OKC Energy FC | - | Louisville City FC | 0:0 | ||||
| 5. Round | 29/08/2021 | OKC Energy FC | - | Rio Grande Valley FC | 2:1 | ||||
| 6. Round | 02/09/2021 | Memphis 901 | - | OKC Energy FC | 0:1 |  |
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| 6. Round | 04/09/2021 | Sporting Kansas City 2 | - | OKC Energy FC | 3:0 | |
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| 6. Round | 12/09/2021 | OKC Energy FC | - | Louisville City FC | 1:1 | |
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| 6. Round | 19/09/2021 | Birmingham Legion | - | OKC Energy FC | 1:1 | |
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| 6. Round | 26/09/2021 | OKC Energy FC | - | Indy Eleven | 2:0 | ||||
| 6. Round | 30/09/2021 | OKC Energy FC | - | Indy Eleven | 1:1 | |
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| 7. Round | 03/10/2021 | OKC Energy FC | - | San Antonio FC | 0:1 | |
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| 7. Round | 11/10/2021 | Austin Bold | - | OKC Energy FC | 1:1 | ||||
| 7. Round | 17/10/2021 | OKC Energy FC | - | Birmingham Legion | 0:0 | ||||
| 7. Round | 25/10/2021 | El Paso Locomotive | - | OKC Energy FC | 4:0 | ||||
| 7. Round | 31/10/2021 | FC Tulsa | - | OKC Energy FC | 2:0 |
USA