| 1. Round | 08/08/2009 | AS Saint-Étienne | - | OGC Nice | 0:2 | ||||
| 2. Round | 16/08/2009 | OGC Nice | - | Stade Rennais | 1:1 | ||||
| 3. Round | 23/08/2009 | Girondins Bordeaux | - | OGC Nice | 4:0 |  |
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| 4. Round | 29/08/2009 | OGC Nice | - | Montpellier HSC | 0:3 | ||||
| 5. Round | 13/09/2009 | AJ Auxerre | - | OGC Nice | 2:0 | ||||
| 7. Round | 27/09/2009 | Lille OSC | - | OGC Nice | 1:1 | ||||
| 8. Round | 03/10/2009 | OGC Nice | - | Valenciennes FC | 3:2 | ||||
| 9. Round | 18/10/2009 | FC Lorient | - | OGC Nice | 4:1 | ||||
| 10. Round | 24/10/2009 | OGC Nice | - | Olympique Lyonnais | 4:1 | ||||
| 12. Round | 01/11/2009 | OGC Nice | - | Le Mans UC 72 | 1:0 | ||||
| 13. Round | 07/11/2009 | Paris Saint-Germain | - | OGC Nice | 0:1 | ||||
| 14. Round | 22/11/2009 | OGC Nice | - | Toulouse FC | 1:0 | ||||
| 15. Round | 28/11/2009 | FC Sochaux | - | OGC Nice | 1:0 | |
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| 16. Round | 05/12/2009 | OGC Nice | - | Olympique Marseille | 1:3 | |
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| 17. Round | 12/12/2009 | RC Lens | - | OGC Nice | 2:0 | ||||
| 18. Round | 19/12/2009 | Grenoble Foot 38 | - | OGC Nice | 1:1 | ||||
| 20. Round | 16/01/2010 | Montpellier HSC | - | OGC Nice | 1:0 | ||||
| 23. Round | 06/02/2010 | OGC Nice | - | Lille OSC | 1:1 | ||||
| 26. Round | 27/02/2010 | Olympique Lyonnais | - | OGC Nice | 2:0 |
France