| 3. Round | 27/08/2010 | FC Eindhoven | - | Fortuna Sittard | 3:0 | ||||
| 8. Round | 01/10/2010 | Fortuna Sittard | - | SC Cambuur | 2:1 | ||||
| 9. Round | 15/10/2010 | RBC Roosendaal | - | Fortuna Sittard | 3:1 | ||||
| 10. Round | 22/10/2010 | Fortuna Sittard | - | FC Dordrecht | 1:2 |  |
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| 11. Round | 30/10/2010 | Fortuna Sittard | - | BV Veendam | 3:3 | ||||
| 12. Round | 05/11/2010 | Go Ahead Eagles | - | Fortuna Sittard | 3:0 | ||||
| 17. Round | 13/12/2010 | RKC Waalwijk | - | Fortuna Sittard | 2:3 | |
Netherlands