| 24. Round | 29/01/2022 | FC Eindhoven | - | MVV | 1:0 | ||||
| 25. Round | 04/02/2022 | MVV | - | VVV-Venlo | 0:5 | ||||
| 26. Round | 11/02/2022 | ADO Den Haag | - | MVV | 2:3 |  |
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| 29. Round | 04/03/2022 | MVV | - | NAC Breda | 1:2 | ||||
| 30. Round | 11/03/2022 | FC Den Bosch | - | MVV | 3:1 | ||||
| 27. Round | 14/03/2022 | MVV | - | AZ Alkmaar (J) | 2:3 | ||||
| 31. Round | 18/03/2022 | De Graafschap | - | MVV | 1:3 | ||||
| 35. Round | 15/04/2022 | MVV | - | SBV Excelsior | 1:1 |
Netherlands