| 11. Round | 16/10/2010 | Sporting Charleroi | - | Sporting Lokeren | 1:2 | ||||
| 12. Round | 24/10/2010 | Sporting Lokeren | - | Club Brugge KV | 1:0 | ||||
| 14. Round | 06/11/2010 | Lierse SK (old) | - | Sporting Lokeren | 2:2 | ||||
| 15. Round | 13/11/2010 | Sporting Lokeren | - | Sint-Truidense VV | 3:0 | ||||
| 16. Round | 20/11/2010 | Sporting Lokeren | - | KV Mechelen | 3:1 | ||||
| 17. Round | 18/01/2011 | KV Kortrijk | - | Sporting Lokeren | 0:0 | ||||
| 23. Round | 23/01/2011 | KAA Gent | - | Sporting Lokeren | 2:1 | ||||
| 24. Round | 29/01/2011 | Sporting Lokeren | - | KAS Eupen | 0:2 | ||||
| 20. Round | 02/02/2011 | Sporting Lokeren | - | Cercle Brugge | 2:1 | ||||
| 25. Round | 06/02/2011 | Germinal Beerschot | - | Sporting Lokeren | 1:1 |  |
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| 26. Round | 12/02/2011 | Sporting Lokeren | - | Sporting Charleroi | 1:1 | |
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| 21. Round | 16/02/2011 | KVC Westerlo | - | Sporting Lokeren | 1:2 | ||||
| 27. Round | 19/02/2011 | Club Brugge KV | - | Sporting Lokeren | 2:1 | ||||
| 28. Round | 05/03/2011 | Sporting Lokeren | - | SV Zulte Waregem | 2:1 | ||||
| 29. Round | 12/03/2011 | Sporting Lokeren | - | Lierse SK (old) | 1:1 | ||||
| 30. Round | 20/03/2011 | Sint-Truidense VV | - | Sporting Lokeren | 0:2 |
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