| 2. Round | 15/02/2022 | Defensa y Justicia II | - | Racing Club II | 1:0 | ||||
| 4. Round | 26/02/2022 | Defensa y Justicia II | - | Gimnasia de La Plata II | 2:1 | ||||
| 6. Round | 12/03/2022 | Argentinos Juniors II | - | Defensa y Justicia II | 0:1 | ||||
| 8. Round | 01/04/2022 | Defensa y Justicia II | - | River Plate II | 2:0 | ||||
| 9. Round | 08/04/2022 | Talleres de Córdoba II | - | Defensa y Justicia II | 1:2 | ||||
| 11. Round | 20/04/2022 | Sarmiento de Junín II | - | Defensa y Justicia II | 0:1 |
Argentina