| 1. Round | 16/07/2021 | Independiente II | - | Argentinos Juniors II | 3:0 | ||||
| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 3. Round | 27/07/2021 | Arsenal de Sarandí II | - | Argentinos Juniors II | 3:1 | ||||
| 4. Round | 02/08/2021 | Argentinos Juniors II | - | Central Córdoba SdE II | 1:0 | ||||
| 7. Round | 20/08/2021 | San Lorenzo II | - | Argentinos Juniors II | 1:3 | ||||
| 8. Round | 26/08/2021 | Argentinos Juniors II | - | Talleres de Córdoba II | 0:1 | ||||
| 9. Round | 30/08/2021 | Unión de Santa Fe II | - | Argentinos Juniors II | 1:2 | ||||
| 10. Round | 03/09/2021 | Estudiantes II | - | Argentinos Juniors II | 2:0 | ||||
| 16. Round | 17/10/2021 | Atlético Tucumán II | - | Argentinos Juniors II | 0:0 | ||||
| 17. Round | 21/10/2021 | Argentinos Juniors II | - | Colón de Santa Fe II | 2:1 | ||||
| 18. Round | 26/10/2021 | River Plate II | - | Argentinos Juniors II | 0:3 | ||||
| 19. Round | 01/11/2021 | Argentinos Juniors II | - | Lanús II | 2:1 | ||||
| 20. Round | 09/11/2021 | Huracán II | - | Argentinos Juniors II | 1:0 |
Argentina