| 1. Round | 04/02/2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
| 6. Round | 12/03/2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
| 7. Round | 21/03/2022 | General Caballero DJLM | - | Guaireña FC | 0:1 | ||||
| 8. Round | 03/04/2022 | Sol de América | - | General Caballero DJLM | 2:3 | ||||
| 9. Round | 09/04/2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
| 10. Round | 18/04/2022 | Resistencia SC | - | General Caballero DJLM | 2:1 | ||||
| 11. Round | 20/04/2022 | General Caballero DJLM | - | 12 de Octubre de Itauguá | 0:0 | ||||
| 12. Round | 24/04/2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | ||||
| 13. Round | 30/04/2022 | General Caballero DJLM | - | Libertad | 0:1 |  |
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| 14. Round | 07/05/2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
| 15. Round | 10/05/2022 | General Caballero DJLM | - | Sportivo Ameliano | 0:3 |  |
Argentina