| 1. Round | 09/08/2008 | AS Monaco | - | Paris Saint-Germain | 1:0 | ||||
| 5. Round | 13/09/2008 | AS Monaco | - | FC Lorient | 2:0 | ||||
| 6. Round | 21/09/2008 | Olympique Marseille | - | AS Monaco | 0:0 | ||||
| 7. Round | 28/09/2008 | AS Monaco | - | Lille OSC | 0:2 | ||||
| 8. Round | 05/10/2008 | AS Saint-Étienne | - | AS Monaco | 2:0 | ||||
| 9. Round | 18/10/2008 | AS Monaco | - | OGC Nice | 1:2 |  |
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| 10. Round | 25/10/2008 | Toulouse FC | - | AS Monaco | 0:0 | ||||
| 11. Round | 29/10/2008 | AS Monaco | - | AS Nancy Lorraine | 3:1 | ||||
| 12. Round | 02/11/2008 | Havre AC | - | AS Monaco | 2:3 | |
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| 13. Round | 08/11/2008 | AS Monaco | - | Olympique Lyonnais | 0:1 | ||||
| 14. Round | 16/11/2008 | Stade Rennais | - | AS Monaco | 2:1 | |
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| 15. Round | 23/11/2008 | AS Monaco | - | Le Mans UC 72 | 3:0 | ||||
| 16. Round | 29/11/2008 | AJ Auxerre | - | AS Monaco | 0:1 | ||||
| 17. Round | 07/12/2008 | AS Monaco | - | FC Sochaux | 1:1 | ||||
| 18. Round | 13/12/2008 | Valenciennes FC | - | AS Monaco | 3:1 | |
Argentina