| Qual. 2. Round | 17/10/2021 | AS Maniema Union | - | Mamelodi Sundowns | 2:2 | ||||
| Group A | 11/02/2022 | Mamelodi Sundowns | - | Al Hilal Omdurman | 1:0 | ||||
| Group A | 02/04/2022 | Mamelodi Sundowns | - | Al Merrikh SC | 3:0 | ||||
| Quarter-finals | 16/04/2022 | Petro Atlético | - | Mamelodi Sundowns | 2:1 | ||||
| Quarter-finals | 23/04/2022 | Mamelodi Sundowns | - | Petro Atlético | 1:1 |
Uruguay